Conjugated hyperbilirubinemia presenting in first fourteen days in term neonates

Table 4 Comparison of causes of early-onset conjugated hyperbilirubinemia and “late-onset” conjugated hyperbilirubinemia between subgroups of clinically well and unwell infants n (%)

	ECHB (n = 65)		LCHB (n = 52)
	Unwell (n = 52)	Well (n = 13)	Unwell (n = 22)	Well (n = 30)
Non-surgical causes
Multifactorial liver injury	39 (75.0)	0 (0)	18 (81.8)	0 (0)
Sepsis	9 (17.3)	0 (0)	3 (13.6)	0 (0)
Inborn errors of metabolism	3 (5.8)	0 (0)	1 (4.5)	0 (0)
CMV infection	0 (0)	0 (0)	0 (0)	2 (6.7)
Idiopathic	0 (0)	5 (38.5)	0 (0)	21 (70.0)
Surgical causes
Biliary atresia	0 (0)	8 (61.5)	0 (0)	5 (16.7)
Choledochal cyst	1 (1.9)	0 (0)	0 (0)	2 (6.7)

ECHB: Early-onset conjugated hyperbilirubinemia; LCHB: “Late-onset” conjugated hyperbilirubinemia; CMV: Cytomegalovirus.