Conjugated hyperbilirubinemia presenting in first fourteen days in term neonates

Table 3 Factors associated with multifactorial liver injury n (%)

Factors associated with multifactorial liver injury	ECHB (n = 39)	LCHB (n = 18)	Total (n = 57)
Antibiotics	38 (97.4)	18 (100.0)	56 (98.2)
Parenteral nutrition	35 (89.7)	16 (88.9)	51 (89.5)
Sedatives/opioid	29 (74.4)	14 (77.8)	43 (75.4)
Mechanical ventilation	26 (66.7)	12 (66.7)	38 (66.7)
Inotropic support	23 (59.0)	9 (50.0)	32 (56.1)
Recent surgery	20 (51.3)	12 (66.7)	32 (56.1)
PPHN	19 (48.7)	4 (22.2)	23 (40.4)
Intestinal obstruction	13 (33.3)	7 (38.9)	20 (35.1)
Congenital heart disease	12 (30.8)	4 (22.2)	16 (28.1)
HFOV	11 (28.2)	3 (16.7)	14 (24.6)
Pneumothorax	8 (20.5)	1 (5.6)	9 (15.8)
CDH	5 (12.8)	4 (22.2)	9 (15.8)
MAS	6 (15.4)	2 (11.1)	8 (14.0)
Renal impairment	6 (15.4)	2 (11.1)	8 (14.0)
Seizures/anti-epileptic	4 (10.3)	2 (11.8)	6 (10.7)
Perinatal asphyxia	3 (7.7)	3 (16.7)	6 (10.5)
Intracranial haemorrhage	2 (5.1)	1 (5.6)	3 (5.3)
Trisomy 21	2 (5.1)	1 (5.6)	3 (5.3)
ECMO	2 (5.1)	1 (5.6)	3 (5.3)
Turner’s syndrome	1 (2.6)	0	1 (1.8)
Trisomy 18	1 (2.6)	0	1 (1.8)

ECHB: Early-onset conjugated hyperbilirubinemia; LCHB: “Late-onset” conjugated hyperbilirubinemia; PPHN: Persistent pulmonary hypertension of the newborn; HFOV: High frequency oscillatory ventilation; CDH: Congenital diaphragmatic hernia; MAS: Meconium aspiration syndrome; ECMO: Extra-corporeal membrane oxygenation.