Regional differences in genetic susceptibility to non-alcoholic liver disease in two distinct Indian ethnicities

Table 3 Association of variants with clinical data

	Ancestral South Indians								North-East Indians
	CC	CT	TT	GG	GA	AA	χ2	P value1	CC	CT	TT	GG	GA	AA	χ2	P value1
TM6SF2 rs58542926
BMI
< 22.9	49	12	2				0.03	0.98	75	18	5				8.24	0.01
> 22.9	110	28	4						94	47	2
PNPLA3 rs2281135
BMI
< 22.9				38	23	2	0.59	0.74				48	37	10	0.077	0.96
> 22.9				82	52	8						71	58	14
TM6SF2 rs58542926
ALT
< 30	89	17	1				6.52	0.038	65	20	1				2.45	0.29
> 30	56	19	5						108	42	7
PNPLA3 rs2281135
ALT
< 30				64	39	4	1.3	0.52				54	28	4	10.27	0.005
> 30				42	33	5						66	71	19
TM6SF2 rs58542926
AST
< 30	90	18	0				10.19	0.006	68	20	3				0.96	0.61
> 30	55	18	6						105	42	5
PNPLA3 rs2281135
AST
< 30				65	40	3	2.89	0.23				54	30	7	5.55	0.06
> 30				41	32	6						66	69	16
TM6SF2 rs58542926
TG
< 150	54	13	4				1.64	0.43	58	25	6				3.89	0.14
> 150	33	12	1						60	29	1
PNPLA3 rs2281135
TG
< 150				42	25	8	0.29	0.86				49	32	8	2.49	0.28
> 150				29	14	3						39	40	11
TM6SF2 rs58542926
HDL
> 40	26	5	0				2.03	0.36	49	22	3				0.05	0.97
< 40	57	18	3						59	27	3
PNPLA3 rs2281135
HDL
> 40				20	11	0	2.52	0.28				39	28	7	0.5	0.77
< 40				46	26	6						71	58	14

¹χ² test. BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TG: Triglycerides; HDL: High density lipoprotein.