Use of everolimus in liver transplantation

Table 3 Recommendation for everolimus use in liver transplantation recipients

Indication and regimen	Renoprotective benefit
	EVR in combination with CNI to allow CNI dose reduction
	Management of CNI neurotoxicity
	EVR allows temporary withdrawal of CNI till resolution of neurotoxicity
Patients	LT recipients with renal function > 60 mL/min
	LT recipients proteinuria < 1 g/24 h
Timing	De novo therapy: Initiate EVR at 1 mo from transplant
	Maintenance therapy: Introduce EVR within 1 yr from transplant
	CNI neurotoxicity: Stop CNI and initiate EVR immediately

CNI: Calcineurin inhibitor; EVR: Everolimus; LT: Liver transplantation.