Low serum albumin predicts early mortality in patients with severe hypoxic hepatitis

Table 2 Comparison between patients with severe hypoxic hepatitis who died and survived n (%)

	Died (n = 53)	Survived (n = 22)	P value
Demographics
Age	64.3 ± 17.6	56.3 ± 12.8	0.059
Male gender	35 (66.0)	8 (36.4)	0.018
Race (Chinese/Malay/Indian)	36/13/4	15/7/0	0.373
Pre-existing co-morbidities
Pre-existing ischemic heart disease	27 (50.9)	12 (54.5)	0.793
Pre-existing cardiac failure	16 (30.2)	11 (50.0)	0.104
Pre-existing renal failure	19 (35.8)	8 (36.4)	0.966
Precipitating conditions
Documented hypotension	45 (84.9)	14 (63.6)	0.041
Documented bradycardia	9 (17.0)	2 (9.1)	0.379
Documented metabolic acidosis	33 (62.3)	10 (45.5)	0.180
Baseline laboratory parameters1
Albumin (g/L)	23.7 ± 6.8	29.1 ± 5.8	0.001
Bilirubin (μmol/L)	79.2 ± 84.4	68.8 ± 79.7	0.625
ALT (U/L)	2051 ± 1601	2880 ± 1674	0.048
AST (U/L)	5093 ± 2943	4440 ± 3103	0.395
ALT/AST ratio_D12	0.50 ± 0.80	1.18 ± 2.15	0.051
GGT (U/L)	111 ± 67	158 ± 123	0.161
Creatine kinase	2949 ± 6180	395 ± 419	0.006
Creatine kinase MB	37.1 ± 56.6	13.5 ± 20.7	0.015
Troponin T (Trop T)	2.02 ± 4.21	0.49 ± 1.42	0.031
Lactate dehydrogenase	2503 ± 2552	4035 ± 3671	0.229
Creatinine (mmol/L)	297.3 ± 172.9	376.6 ± 276.3	0.143
Prothombin time (seconds)	27.8 ± 12.5	27.7 ± 11.9	0.980
Peak ALT (U/L)	2572 ± 2026	3464 ± 1575	0.069
Peak AST (U/L)	6223 ± 3138	5131 ± 3110	0.176

¹Measured at onset of severe hypoxic hepatitis;

²Ratio of the ALT to AST at the first documentation of either ALT or AST > 3000 U/L. AST: Aspartate transaminase; ALT: Alanine transaminase; GGT: Gamma glutamyl transferase.