Early acute kidney injury after liver transplantation: Predisposing factors and clinical implications

Table 4 Logistic regression analysis of variables associated with early acute kidney injury after liver transplantation

	Univariate analysis		Multivariate model
Variables	Odds ratio (95%CI)	P value	Odds ratio (95%CI)	P value
Male gender	1.088 (0.49-2.44)	0.837	0.430 (0.07-2.55)	0.352
Weight	1.020 (0.99-1.05)	0.164	1.026 (0.96-1.10)	0.455
Age	1.034 (0.999-1.07)	0.058	1.121 (1.02-1.23)	0.019
Pre-transplant
Diabetes mellitus	2.130 (0.92-4.92)	0.077	2.429 (0.48-12.41)	0.286
Hypertension	1.197 (0.43-3.36)	0.733	0.593 (0.04-8.04)	0.694
Serum creatinine	1.000 (0.99-1.01)	0.937	0.979 (0.96-1.002)	0.078
MELD	1.010 (0.97-1.05)	0.639	0.992 (0.91-1.08)	0.845
Haemoglobin	0.985 (0.97-1.002)	0.076	0.977 (0.93-1.02)	0.311
Graft characteristics
DCD organ	1.488 (0.52-4.23)	0.455	2.638 (0.30-23.12)	0.381
Donor age	0.984 (0.96-1.01)	0.218	0.964 (0.92-1.01)	0.160
Cold ischaemic time	1.001 (0.99-1.004)	0.498	1.000 (0.99-1.01)	0.984
Peak serum AST < 24 h post OLT	1.001 (1.00-1.001)	0.001	1.001 (1.00-1.001)	0.020
Perioperative course
Caval replacement surgical technique	2.160 (1.03-4.54)	0.042	3.289 (0.71-15-25)	0.128
Noradrenaline infusion rate on ICU arrival	4.830 (0.19-125.48)	0.343	47.468 (0.12-1836.27)	0.204
RCC transfusion	1.137 (1.03-1.26)	0.014	0.917 (0.64-1.32)	0.645
FFP transfusion	1.201 (1.07-1.35)	0.003	1.118 (0.84-1.48)	0.440
Platelet transfusion	1.499 (1.04-2.16)	0.030	1.948 (0.871-4.36)	0.104
Cell salvage volume	1.001 (1.00-1.001)	0.025	1.00 (0.999-1.002)	0.808

CI: Confidence interval; MELD: Model for End-Stage Liver Disease; DCD: Donation after Cardiac death; ICU: Intensive care unit; RCC: Red cell concentrate; FFP: Fresh frozen plasma; AST: Aspartate aminotransferase; OLT; Orthotopic liver transplantation.