Systemic treatment of hepatocellular carcinoma: Past, present and future

Table 1 Doxorubicin as first line treatment in hepatocellular carcinoma

Ref.	n	Line/treatment	Relevant data
Nagahama et al[21]	147	First line doxorubicin	Severe cirrhosis, PS 2-3, tumour occupying > 50% liver do not respond to chemo
Olweny et al[22]	14	First line doxorubicin	RR 79%
Sciarrino et al[23]		First line doxorubicin	RR 10%-20%
Chlebowski et al[24]

RR: Response rate.