Inducible protein-10 as a predictive marker of antiviral hepatitis C treatment: A systematic review

Table 8 Overview of sustained viral response in the 8 studies providing information on baseline inducible protein-10’s, and hepatitis C virus-RNA levels 24 wk after end-of- treatment

Ref.	Patients (n)	IP-10 measurement method	Genotype (n)	Baseline IP-10 concentration, grouped by sustained virological response (pg/mL)			Overall SVR
				SVR	Non-SVR	P-value	SVR	Non-SVR
Apolinario et al[9]	63	ELISA (OptEIA, Pharmingen, San Diego, CA, United States)	1 (43)	245 (± 154)	381 (± 138)	P < 0.05 (mean ± SD)	36	27
Diago et al[7]	137	ELISA (Human immunoassay kit; BioSource Europe SA, Nivelles, Belgium	1 (103)	347 (± 197.4)	500.6 (± 311.2)	P < 0.01 (mean ± SD)	792	582
			1 (103)	332.4 (± 222.1)	476.8 (± 305.3)	P < 0.01 (mean ± SD)
			2 (9)
			3 (25)
1Fattovich et al[21]	226	ELISA (Quantikine, R and D systems, Minneapolis, MN, United States )	1 (92)	2.47 ± 0.23	2.65 ± 0.28	P < 0.001 (log mean ± SD)	2092	712
			2 (87)	2.37 ± 0.31	2.33 ± 0.35	P > 0.05 (log mean ± SD)
			3 (47)	2.42 ± 0.21	2.67 ± 0.46	P < 0.05a (log mean ± SD)
Kurelac et al[33]	46	ELISA (Quantikine, R and D systems, Minneapolis, MN, United States )	1 (46)	185 (63-518)	395.5 (111-926)	P < 0.0001 (median, range)	26	20
Darling et al[31]	272	ELISA (Quantikine, R and D systems, Minneapolis, MN, United States )	1 (272)	437 (± 31)	704 (± 44)	P < 0.001 (mean ± SD)	157	115
Derbala et al[32]	159	Luminex, Cytokine multiplex immunoassay kit (Merck Millipore, Billerica, MA, United States)	4 (159)	Exact data not provided, only graphic presentation		P < 0.001 (median, IQR)	98	61
Al-Ashgar et al[19]	64	ELISA (Quantikine, R andD systems, Minneapolis, MN, United States )	4 (64)	462 (± 282.6)	840.4 (± 490.6)	P < 0.01 (mean ± SD)	41	23

¹Entire patina population was 280, genotype 4 removed from the analyses, and IP-10 results was available for 226 patients Note that M. Derbala et al did not provide written specification on IP-10 levels for SVR compared to non-SVR, and only supplied a graphic depiction, which could not be interpreted to adequate results;

²SVR for the entire population.

^aP = 0.02. Only the results of statistical tests with a P value < 0.01 were considered of interest, because of the multiple comparisons between subjects with and without SVR. SVR: Sustained viral response; IP-10: Inducible protein-10.