Inducible protein-10 as a predictive marker of antiviral hepatitis C treatment: A systematic review

Table 3 Hepatitis C virus-RNA and patient liver enzyme status for the 8 included studies

Ref.	HCV-RNA					Liver enzyme level
	High viral load		Low viral load		All patients	AST	ALT
	n	Limit	n	Limit
Apolinario et al[9]	28	≥ 6.3 log IU/mL5	35	< 6.3 log IU/mL5			118 IU/L (± 64) $
1Lagging et al[34]
IL28B rs12979860 CC					6.3 log IU/mL (± 0.8)3	Information not provided
IL28B rs12979860 CT					6.1 log IU/mL (± 0.7)3
IL28B rs12979860 TT					5.9 log IU/mL (± 0.8)3
Diago et al[7]	85	≥ 5.7 log IU/mL5	52	< 5.7 log IU/mL5			117.2 IU/L (± 81.6)3
Fattovich et al[21]	147	≥ 5.6 log IU/mL5			5.74 log IU/mL (± 0.9)35		92 IU/L (± 78)3
Kurelac et al[33]					5.55 log IU/mL (5.52-6.1)25	Information not provided
Darling et al[31]					6.66 log IU/mL (± 6.76)35		90.9 IU/L (72.9)3
Darbala et al[32]					4.95 log IU/mL (3.6-5.63)45	38 IU/L (27-51)4	51 IU/L (34-87)4
Al-Ashgar et al[19]	45	≥ 5.78 log IU/mL	19	< 5.78 log IU/mL5		67.5 IU/L (43.5-106.8)2	56.0 IU/L (32.0-86.0)2

¹Lagging et al provided baseline demographics in accordance with IL-28 genotype (only baseline characteristics for rs12979860 are reported in the review, as these were representative for the study population);

²Median (25-75 percentiles);

³Mean (SD);

⁴Median (IQR);

⁵Recalculated into log IU/mL. HCV-RNA is shown as number of patients with high or low viral load or as the mean or median for the entire population. Depending of the presentation in the original article, levels of ALT, AST or both are shown. HCV: Hepatitis C virus; ALT: Alanine transaminase; AST: Aspartate transaminase.