Review
Copyright ©The Author(s) 2017.
World J Hepatol. May 18, 2017; 9(14): 645-656
Published online May 18, 2017. doi: 10.4254/wjh.v9.i14.645
Table 1 Summary of hepatocellular carcinoma radiotherapy studies
Ref.No. of patientsPercent of Child-Pugh B patientsMedian tumor diameter (range), cmDose (range)/No. of fractionsMedian follow-up interval, mo1-yr OS2-yr LCToxicity
Scorsetti et al[68], 20154336%≤ 6 cm48-75 Gy/3 (51%) and 36-60 Gy/6 (49%)877.9%64.4%≥ gr3: 0
Yamashita et al[69], 20157911%2.7 cm48 Gy (40-60)/4-102153% at 2 yr40%gr3-4: 4.6% gr2: 2.3%
Huertas et al[70], 20157714.3%2.4 cm45 Gy/31281.899%14.9%
Zhong et al[71], 20147226%13.1 cm35.6 Gy/121856%NRgr1-2: 5.6% liver
gr1-2: 9.8%
gastrointestinal
Lo et al[72], 201453NR4.3 cm40 Gy/4-513.170.1%RILD 9.4%
Van de Voorde et al[73], 20145NRNR93.6 Gy (62.5-150 )/3-102185.4%NR0
Sanuki et al[74], 20146316%2.6 cm35-40 Gy/531.1100%95%gr3:
early: 16%
late: 21%
gr4-5: 0%
Park et al[75], 20132627%2.8 cm40-50 Gy; 4-5 Gy per fraction20.288.5%87.6%gr3: 4%
gr4-5: 0%
Bujold et al[30], 20131020%9.9 cm24-54 Gy (36)/631.475%74%gr3: 21% gr4: 2.9% gr5: 6.9%
Yoon et al[76], 20139326%2 cm45 Gy (30-60)/3-425.686.0%94.8%1 (2 yr)gr3: 4.3%
gr4: 1.0%
gr5: 1.0%
Jang et al[65], 201310810%3.0 cm51 Gy (33-60 )/33083%187%gr3: 6.5%
gr4: 1.9%
gr5: 0%
Jung et al[77], 20139226%Vol: 8.6 cc45 Gy (30-60 )/3-425.786.9%92.1% (3 yr)gr ≥ 3: 7%
Bibault et al[78], 20137511%3.7 cm40-45 Gy/31078.5%89.8%gr3: 4%
gr4: 1.3%
gr5: 0%
Honda et al[79], 20133023%16 cm48 Gy/412.3100%95%1gr3: 10%
gr4-5: 0%
Yuan et al[80], 20132245%4.3 cm45 Gy (39-54)/3-853.473%92.9%gr2: 31.8%
Sanuki et al[81], 201318515%CP-A: 27 cmCP-A: 40 Gy/52495%93% (2 yr)gr5: 1.1%
CP-B: 24 cmCP-B: 35 Gy/5
Xi et al[18], 2013410%Mean GTV vol: 65.4 cc (SD: 47.9)30-48 Gy (36)1050.3%NRgr3: 2.4%
gr4-5: 0%
Huang et al[82], 201236NR1.1-12.3 cm37 Gy (25-48)/4-51464% at 2 yr98%gr2: 3%
Kang et al[83], 20124713%2.9 cm42-60 Gy/31783%194.6%gr3: 6.4%
gr4: 4.3%
gr5: 0%
Ibarra et al[84], 201221NRGTV vol: 334.2 cc30 Gy (18-50 )/1-1012.987%57%1 (2 yr)gr3: 4.8%
gr4: 4.8%
gr5: 0%
Price et al[85], 20122646%Median GTV vol: 33.9 cc42 Gy (24-48 )/3-51377%NRNR
Andolino et al[86], 20116040%3.1 cmCP-A: 30-48 Gy/32782%190% (2 yr)gr3: 35%
CP-B: 24-48 Gy/5gr4: 1.7%
gr5: 0%
Chan et al[87], 20111125%3 cm45 Gy/102462%NRgr ≥ 3 22%
Louis et al[88], 20102512%4.5 cm45 Gy/312.779%95%gr3:
early 8%
late 4%
Kwon et al[89], 20104210%Vol: 15.4 cc30-39 Gy/328.792.9%67.5%gr3: 0%
gr4: 2%
gr5: 0%
Cárdenes et al[66], 20101765%≤ 6 cmCP-A: 48 Gy/3 CP-B: 42 Gy/3 then 40/52475%100%gr3: 13 instances
gr4: 11.8%
gr5: 0%
Son et al[90], 2010478%18.3 cm36 Gy (30-39)/3NRNRNRgr2: 33%
Goyal et al[91], 20106NR9.3 cm34 (24-45 Gy)/1-31083%100% at 9 mo0%
Seo et al[92], 20103811%Vol: 40.5 cc33-57 Gy/3-41568.4%66.4% (local PFS)gr3: 3%
gr4-5: 0%
Choi et al[21], 20082214%Vol: 23.5 cc36 Gy (30-39 )/311.588.1%NRgr3: 4.5%
gr4-5: 0%
Tse et al[61], 2008310%173 cc36 Gy (24-54 )/617.648%NRgr3: 29% gr4-5: 0%
Méndez Romero et al[93], 2006825%3.2 cm< 4 cm: 37.5 Gy/3 ≥ 4 cm: 25 Gy/5 or 30 Gy/312.975%75% (22 mo)gr5: 12.5% RILD