Drug-induced liver injury: Do we know everything?

Table 2 The most common individual drugs and classes responsible for idiosyncratic drug-induced liver injury according to various Global Registries

	Iceland[78], n = 96	India[79], n = 313	Spain[76], n = 446	Sweden[77], n = 784	United States DILIN[72], n = 899
Individual drugs (%)
	Amoxicillin-clavulanate 22.9	INH + anti-TB 57.8	Amoxicillin-clavulanate 13.2	Flucloxacillin 16.5	Amoxicillin-clavulanate 10%
	Diclofenac 6.3	Phenytoin 6.7	INH + anti-TB 6.9	Erythromycin 5.4	INH 5.3%
	Nitrofurantoin 4.2	Dapsone 5.4	Ebrotidine 4.9	Disulfiram 3.4	Nitrofurantoin 4.7%
	Infliximab 4.2	Olanzapine 5.4	Ibuprofen 4	TMP-SMX 2.7	SMX-TMP 3.4%
	Azathioprine 4.2	Carbamazine 2.9	Flutamide 3.8	Diclofenac 2.6	Minocycline 3.1%
	Isotretinoin 3.1	Cotrimoxazole 2.2	Ticlopidine 2.9	Carbamazepine 2.2	Cefazolin 2.2%
	Atorvastatin 2.1	Atorvastatin 1.6	Diclofenac 2.7	Halothane 1.9	Azithromycin 2%
	Doxycycline 2.1	Leflunamide 1.3	Nimesulide 2	Naproxen 1.4	Ciprofloxacin 1.8%
		Ayurvedic 1.3	Carbamazepine 1.8	Ranitidine 1.3	Levofloxacin 1.4%
Drug classes (%)
Antibiotics	37	65	32	27	45.4
HDS	16	1.3	2	NS	16.1
CNS	7	12	17	3	9.8
Hypolipidemic	3.1	1.6	5	1	3.7
Others	37	20	44	69	25.7

United States DILIN: United States Drug-Induced Liver Injury Network; INH: Isoniazid; SMX: Sulfamethoxazole; TMP: Trimethoprim; TB: Tuberculosis; HDS: Herbal and dietary supplements; CNS: Central nervous system; NS: Not specified.