Comprehensive review of telbivudine in pregnant women with chronic hepatitis B

Table 3 Non-overlapping literature references of telbivudine exposure during pregnancy

Ref.	Original language	Study design	LdT starting trimester during pregnancy	No. of pregnancy with exposure to LdT	Maternal HBV DNA (at inclusion)
Chen et al[46]	Chinese	Prospective	1st trimester	43	≥ 1 × 107 copies/mL
Han et al[47]	English	Prospective	2nd and 3rd trimesters	362	> 1.0 × 106 copies/mL
Jiang et al[53]	Chinese	Prospective	3rd trimesters	28	> 103 copies/mL (at inclusion)
Liu et al[38]	Chinese	Prospective	3rd trimester	5	≥ 1 × 107 copies/mL (before treatment)
Liu et al[28]	English	Prospective	1st trimester	89	> 1 × 105 copies/mL
Liu et al[21]	English	Prospective	1st, 2nd or 3rd trimesters	82	≥ 106 IU/mL
Mohan et al[54]	English	Prospective	1st trimester	1	4.0433 × 104 copies/mL
Peng et al[39]	Chinese	Prospective	3rd trimester	40	≥ 1 × 106 copies/mL
Wu et al[27]	English	Prospective	2nd or 3rd trimester	279	> 106 IU/mL
Yu et al[44]	English	Prospective	1st, 2nd or 3rd trimester	233	> 1.0 × 106 copies/mL
Zeng et al[40]	Chinese	Prospective	3rd trimester	22	≥ 105 copies/mL
Zeng et al[22]	English	Prospective	1st or 3rd trimester	54	Not reported
Zhao et al[55]	Chinese	Prospective	3rd trimester	30	Not reported
Zhang et al[41]	Chinese	Prospective	3rd trimester	31	> 1 × 107 copies/mL
Zhang et al[42]	Chinese	Prospective	3rd trimester	60	≥ l × 106 copies/mL
Zhang et al[26]	English	Prospective	3rd trimester	257	> 6 log10 copies/mL
Zhou et al[43]	Chinese	Prospective	3rd trimester	36	≥ 1 × 107 copies/mL
Zhou et al[45]	Chinese	Prospective	1st trimester	73	≥ 1 × 107 copies/mL