Management of human factors engineering-associated hemochromatosis: A 2015 update

Table 1 Classification of iron overload and hemochromatosis

Genetic iron overload (primary)

Type 1 HFE-associated hemochromatosis

C282Y homoyzygosity

C282Y/H63D compound heterozygosity

Type 2 juvenile hemochromatosis

2A hemojuvelin mutations

2B hepcidin mutations

Type 3 TfR2-related hemochromatosis

Transferrin receptor 2

Type 4 ferroportin disease

Loss of function mutations, also called type 4A or "M"

Hepcidin resistance mutations, also called type 4B or "H"

Aceruloplasminemia

Ceruloplasmin mutations

A(hypo)transferrinemia

Acquired iron overload (secondary)

Ineffective erythropoiesis

Thalassemia major

Sideroblastic anemia

Chronic hemolytic anemia

Dietary iron overload (African)

Parenteral iron overload (including transfusional overload)

HFE: Human factors engineering.