Case Control Study
Copyright ©The Author(s) 2016.
World J Hepatol. Feb 18, 2016; 8(5): 291-300
Published online Feb 18, 2016. doi: 10.4254/wjh.v8.i5.291
Table 1 Clinical features of patients with active hepatitis C virus infection (active hepatitis C virus group) and of those in whom hepatitis C virus infection was eradicated (eradication group) n (%)
Discrete traitsActive HCV group (n = 55)Eradication group (n = 55)P value
Sex0.254
Male22 (40)28 (51)
Female33 (60)27 (49)
HCV genotype0.003
1b48 (87)36 (65)
27 (13)19 (35)
Quantitative traitsMean ± SDMean ± SD
Age (yr)66.9 ± 11.264.3 ± 12.10.200
BMI (kg/m2)22.5 ± 3.222.8 ± 3.40.631
AST (IU/L)53.1 ± 27.524.0 ± 7.2< 0.001
ALT (IU/L)49.9 ± 37.120.0 ± 11.7< 0.001
Total bilirubin (mg/dL)0.8 ± 0.30.7 ± 0.30.242
γ-GTP (IU/L)50.4 ± 6427.1 ± 200.011
Albumin (g/dL)3.9 ± 0.44.4 ± 0.3< 0.001
Hb (g/dL)13.4 ± 1.714.2 ± 1.50.010
Platelet (104/μL)15.0 ± 6.320.0 ± 17.80.050
FBG (mg/dL)108 ± 32107 ± 160.740
HbA1c (%)5.4 ± 0.66.1 ± 0.50.030
Lipid profiles
Total cholesterol (mg/dL)173.6 ± 31200.5 ± 37.8< 0.001
Triglyceride (mg/dL)107.5 ± 52.0103 ± 53.10.712
LDL cholesterol (mg/dL)92.1 ± 25.7117 ± 29.9< 0.001
HDL cholesterol (mg/dL)59.9 ± 17.464.9 ± 19.00.159
CETP level (μg/mL)2.84 ± 1.002.40 ± 0.690.008
There were significant differences in the proportion of patients with HCV G1b infection. There were no significant differences in BMI, FBG levels, and HbA1c levels, whereas AST, ALT, and albumin levels differed significantly. TC and LDL-C levels were significantly lower in the active infection group than in the eradication group, whereas TG and HDL-C levels were similar in the two groups. HCV: Hepatitis C virus; BMI: Body mass index; AST: Aspartate-2-oxoglutarate aminotransferase; ALT: Alanine-2-oxoglutarate aminotransferase; γ-GTP: Gamma-glutamyl transpeptidase; Hb: Hemoglobin; FBG: Fasting blood glucose; HbA1c: Glycosylated hemoglobin; LDL: Low-density lipoprotein; HDL: High-density lipoprotein; CETP: Cholesterol ester transfer protein; LDL-C: Low-density lipoprotein cholesterol.