Fractionation of gamma-glutamyltransferase in patients with nonalcoholic fatty liver disease and alcoholic liver disease

Table 1 Comparison of the characteristics of the controls and study patients with biopsy proven

	Biopsy-proven ALD	Biopsy-proven NAFLD	Clinically diagnosed NAFLD	Controls	P value
	(n = 14)	(n = 9)	(n = 16)	(n = 10)	Biopsy-proven ALD vs NAFLD
Age (yr)	53 (45-60)	54 (49-66)	49 (43-54)	51 (39-60)	NS
Gender (male:female)	11:3	6:3	16:0	10:0	NS
AST (U/L)	74 (41-105)	45 (38-95)	32 (24-42)	19 (15-21)	NS
ALT (U/L)	19 (13-22)	35 (27-67)	48 (35-74.5)	18 (14-20)	0.0166
Albumin (g/dL)	4.1 (3.2-4.4)	4.6 (4.1-4.7)	4.4 (4.3-4.6)	4.6 (4.3-4.8)	NS
Total bilirubin (mg/dL)	1 (0.6-3.1)	0.7 (0.6-0.8)	0.8 (0.6-0.9)	0.9 (0.6-1.2)	NS
Triglyceride (mg/dL)	186 (99-284)	184 (101-298)	187 (102-212)	130 (111-139)	NS
HDL-cholesterol (mg/dL)	40 (30-56)	43 (29-52)	42 (39-54)	50 (42-56)	NS
LDL -cholesterol (mg/dL)	75 (43-105)	116 (97-153)	122 (98-157)	113 (101-136)	0.0181
GGT (U/L)	368 (296-421)	94 (62-170)	74 (57-112)	24 (19-42)	0.0018
b/t-GGT ratio	0.1 (0.07-0.13)	0.16 (0.13-0.26)	0.18 (0.14-0.24)	0.12 (0.08-0.15)	NS
m/t-GGT ratio	0.04 (0.02-0.05)	0.04 (0.02-0.05)	0.04 (0.03-0.05)	0.02 (0.02-0.03)	NS
s/t-GGT ratio	0.78 (0.65-0.80)	0.55 (0.49-0.64)	0.54 (0.49-0.60)	0.4 (0.31-0.44)	0.0158
f/t-GGT ratio	0.12 (0.08-0.15)	0.18 (0.15-0.26)	0.23 (0.15-0.29)	0.45 (0.37-0.63)	0.0055
b/s-GGT ratio	0.14 (0.09-0.20)	0.33 (0.21-0.53)	0.35 (0.24-0.51)	0.29 (0.19-0.52)	0.0456
s/f-GGT ratio	6.68 (3.67-10.58)	3.1 (2.18-4.32)	2.09 (1.69-3.98)	0.96 (0.48-1.11)	0.0086

Data are presented as median (25^th-75^th percentile). Statistical analysis: Wilcoxon-Mann-Whitney U test. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyltransferase; ALD: Alcoholic liver disease; NAFLD: Non-alcoholic fatty liver disease; NS: Not significant; HDL: High density lipoprotein; LDL: Low density lipoprotein; b-GGT: Big-GGT; m-GGT: Medium-GGT; s-GGT: Small-GGT; f-GGT: Free-GGT.