Toll-like receptors in pathophysiology of liver diseases

Figure 1 Toll-like receptors signaling pathways. TLR: Toll-like receptors; LPS: Lipopolysaccharide; NF-κB: Nuclear factor; IFNs: Interferons; LBP: LPS-binding protein; TIRF: Toll/interleukin-1 receptor-domain-containing adaptor-inducing interferon-β; MyD88: Myeloid differentiation primary response protein 88; TRAM: TRIF-related adaptor molecule; TIRAP: TIR domain-containing adaptor protein; IRAK: IL-1 receptor-associated kinase; TRAF: Tumor necrosis factor receptor-associated factor; TBK1: TANK binding kinase-1; IKK: IκB kinase; AP: Activator protein; JNK: c-Jun N-terminal kinase.