Novel non-invasive biological predictive index for liver fibrosis in hepatitis C virus genotype 4 patients

Table 2 Presentation of quantitative variables and their significance among three levels of fibrosis and significance between groups

Variant	Mild fibrosis (F0-F1) (n = 179)	Moderate fibrosis (F2) (n = 64)	Advanced fibrosis (F3-F4) (n = 89)	P1	P2	P3
Age (yr)
Mean ± SD	39.1 ± 9.6	42 ± 7.4	49 ± 8.2	0.001	0.001	0.001
Median ± QR	38.5 ± 16	42 ± 10	50 ± 11
Gender (male)
n (%)	101 (56)	40 (62)	43 (48)	0.100	0.060	0.832
HOMA-IR
Mean ± SD	2.6 ± 0.9	3.4 ± 1.2	4.1 ± 1.5	0.027	0.001	0.008
Median ± QR	2.5 ± 1.4	3.4 ± 1.4	4.1 ± 2.2
ACE (U/mL)
Mean ± SD	271.5 ± 127.3	287.2 ± 122.5	323.2 ± 150.9	0.051	0.001	0.022
Median ± QR	255 ± 187.5	300 ± 190	275 ± 142.5
Glucose (mmol)
Mean ± SD	5.1 ± 0.9	4.8 ± 0.8	5.4 ± 1	0.629	0.013	0.017
Median ± QR	5 ± 1	4.6 ± 1.1	5.3 ± 1.5
ALT (U/L)
Mean ± SD	50.2 ± 34.9	55.5 ± 30.3	80.7 ± 38.4	0.004	0.001	0.022
Median ± QR	40 ± 43	47 ± 53	85.5 ± 53.3
AST (U/L)
Mean ± SD	38.3 ± 20.3	55 ± 35.4	87.8 ± 48.5	0.001	0.001	0.001
Median ± QR	34 ± 20.5	36 ± 39	87 ± 61
Platelet (× 109/L)
Mean ± SD	237.1 ± 62.4	207.1 ± 70.2	162 ± 59.8	0.003	0.001	0.001
Median ± QR	231 ± 81.3	226 ± 120	160.5 ± 64.3
Insulin (uU/mL)
Mean ± SD	11.9 ± 4.4	15.8 ± 4.9	16.8 ± 5.8	0.016	0.001	0.071
Median ± QR	12.4 ± 6.2	14.6 ± 3.4	16.7 ± 6.4
Creatinine (mg/dL)
Mean ± SD	0.7 ± 0.2	0.6 ± 0.1	0.7 ± 0.2	0.999	0.009	0.039
Median ± QR	0.7 ± 0.2	0.6 ± 0.3	0.6 ± 0.3
Albumin (g/dL)
Mean ± SD	4.3 ± 0.43	4 ± 0.8	4 ± 0.41	0.044	0.001	0.005
Median ± QR	4.4 ± 0.54	4.2 ± 0.84	4 ± 0.67
Viral load1
Range	45979 (2.47-6570282)	36355.5 (2.46-6403601)	55000 (6.00-5600790)	0.37	0.96	0.52
Mean ± SD	358316.6 ± 909311.81	283586 ± 858939.26	331799.1 ± 863675.2

¹Comparison was done using non-parametric Mann-Whitney test. SD: Standard deviation; QR: Quartile range; HOMA-IR: Homeostasis model for insulin resistance, a mathematically calculated formula; ACE: Angiotensin converting enzyme; AST: Aspartate transaminase enzyme; ALT: Alanine amino transferase; P1: Significance between mild and moderate fibrosis; P2: Significance between mild and advanced fibrosis; P3: Significance between moderate and advanced fibrosis.