Changes in cellular proliferation and plasma products are associated with liver failure

Table 3 Potential clinical and inflammatory parameters as indicators of acute liver failure syndrome and death

	Cut-off	Adjusted OR	95%CI	P value
Plasma variables1
IL-6 (pg/mL)	> 197.6	1.36	0.04-40.27	0.856
IL-10 (pg/mL)	> 55.77	18.86	1.38-257.94	0.028
TNFα (pg/mL)	> 122.6	4.42	0.185-105.93	0.359
mtDNA (ng/100 μL plasma)	> 174	320.54	14.42-7123.33	0.000
Plasma variables2
IL-6 (pg/mL)	> 473.2	2.27	0.19-26.92	0.515
IL-8 (pg/mL)	> 66.30	10.42	1.54-70.45	0.016
IL-10 (pg/mL)	> 95.71	8.01	1.26-50.97	0.027
TNFα (pg/mL)	> 313.7	0.27	0.03-2.17	0.220
mtDNA (ng/100 μL plasma)	> 405.3	12.11	2.57-57.07	0.002
INR	> 2.12	29.88	5.44-164.19	0.000

¹Multivariate analysis from clinical and inflammatory parameters associated with ALF;

²Multivariate analysis from clinical and inflammatory parameters associated with death. OR: Odds ratio; IL: Interleukin; IFNγ: Interferon gamma; TNFα: Tumor necrosis factor alpha; mtDNA: Total mitochondrial DNA; ALF: Acute liver failure; INR: International normalized ratio.