Prophylactic liver transplantation for high-risk recurrent hepatocellular carcinoma

Table 1 Comparison between prophylactic liver transplant and wait-and-see before hepatocellular carcinoma recurrence

The strategy	Prophylactic LT	Wait-and-see
Immunosuppressant exposure	Life-long	Nil
Surgical morbidity and mortality	Present	Nil
Long-term HCC recurrence	Lower[32]	Higher[11]
Survival benefit (5-year survival rate)	84.6%[32]	Around 70%[7-10]
Further management after recurrence	Hepatectomy, RFA, TACE, Sorafenib, Yttrium-90	SLT, repeat hepatectomy, RFA, TACE, Sorafenib, Yttrium-90

LT: Liver transplant; RFA: Radiofrequency ablation; TACE: Transcatheter arterial chemoembolization; HCC: Hepatocellular carcinoma.