Sofosbuvir treatment and hepatitis C virus infection

doi:10.4254/wjh.v8.i3.183

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jan 28, 2016; 8(3): 183-190
Published online Jan 28, 2016. doi: 10.4254/wjh.v8.i3.183

Table 2 Summary of phase 3 study for hepatitis C virus genotype 2-infected patients

Study name	Population	Treatment	Duration (wk)	n	LC (%)	SVR12 (%)
						All	Non-LC	LC
FISSION	Naïve	SOF/RBV	12	70	-	97	-	-
POSITRON	IFN-ineligible/intolerant	SOF/RBV	12	109	15	93	92	94
VALENCE	Naïve	SOF/RBV	12	32	-	97	97	100
Japanese study	Naïve	SOF/RBV	12	90	9	98	97	100
FUSION	Experienced	SOF/RBV	12	36	28	86	96	60
			16	32	-	94	100	78
VALENCE	Experienced	SOF/RBV	12	41	-	90	91	88
Japanese study	Experienced	SOF/RBV	12	63	14	95	96	89

LC: Liver cirrhosis; SVR12: Sustained virologic response at 12 wk; Naïve: Treatment-naïve; Experienced: Treatment-experienced; SOF: Sofosbuvir; IFN: Interferon; RBV: Ribavirin.

Citation: Nakamura M, Kanda T, Haga Y, Sasaki R, Wu S, Nakamoto S, Yasui S, Arai M, Imazeki F, Yokosuka O. Sofosbuvir treatment and hepatitis C virus infection. World J Hepatol 2016; 8(3): 183-190
URL: https://www.wjgnet.com/1948-5182/full/v8/i3/183.htm
DOI: https://dx.doi.org/10.4254/wjh.v8.i3.183