Hepatitis C and double-hit B cell lymphoma successfully treated by antiviral therapy

Figure 4 Histological and immunohistochemical features of the diffuse large B cell lymphoma in the second relapse (cutaneous). A: In the cutaneous relapse a rather monomorphic lymphoid population was found; B: The rate of large lymphoid cells increased up to 100%; C: These large cells were B CD20+; D: The proliferation rate marked by Ki67 was around 95% in the blastic B cell population; E: The large B cells expressed poorly the germinal center marker Bcl6; F: Mum1 was found to be poorly expressed by the large B cells. DLBCL: Diffuse large B cell lymphoma; H and E: Hematoxylin and eosin; CD: Clusters of differentiation; Ki67: Cellular marker for proliferation; Bcl6: B Cell lymphoma 6; Mum1: Multiple myeloma oncogene 1.