Hepatitis C and double-hit B cell lymphoma successfully treated by antiviral therapy

Figure 3 Histological and immunohistochemical features of the diffuse large B cell lymphoma at the first relapse (mucosal). A: In the mucosal relapse a polymorphic lymphoid population was found; B: The rate of large lymphoid cells increased up to 80%; C: These large cells were B CD20+; D: The proliferation rate marked by Ki67 was around 50%-60% with respect to the blastic B cell population; E: The large B cells expressed the germinal center marker Bcl6 (about 50%-60%); F: Mum1 was found to be expressed now by about 70% of the cells. DLBCL: Diffuse large B cell lymphoma; H and E: Hematoxylin and eosin; CD: Clusters of differentiation; Ki67: Cellular marker for proliferation; Bcl6: B Cell lymphoma 6; Mum1: Multiple myeloma oncogene 1.