Hepatitis C and double-hit B cell lymphoma successfully treated by antiviral therapy

Figure 1 Histological and immunohistochemical features of the diffuse large B cell lymphoma at the primary diagnosis. A: In the lymph node a polymorphic lymphoid population is seen; B: Large lymphoid cells prevailed; C: These large cells were B CD20+; D: The proliferation rate marked by Ki67 was around 20% with respect to the overall population, but about 40% if compared with the blastic B cell population; E: The large B cells expressed mainly the germinal center marker Bcl6; F: Mum1 was not found expressed at the primary diagnosis. DLBCL: Diffuse large B cell lymphoma; H and E: Hematoxylin and eosin; CD: Clusters of differentiation; Ki67: Cellular marker for proliferation; Bcl6: B cell lymphoma 6; Mum1: Multiple myeloma oncogene 1.