Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma

Figure 1 Scanning electron micrographs of liver tissue at × 500 and × 1500. A and B: Control group, illustrating the central vein (CV), hexagonal hepatocytes (encircled) and biconcave RBCs in sinusoids (arrowed); C: LycT group illustrating hexagonal hepatocytes with bile canaliculi (BC) on theits surface (arrowed); D and E: NDEA group illustrating tumor nodules (encircled) with abnormal cell proliferation and disturbed ultrastructure; F-H: LycT + NDEA group respectively illustrating high cell density, CV, apoptotic bodies (arrowed) along with various alterations and two-three cell plate thickening indicating well-differentiated hepatocellular carcinoma, respectively. LycT: Lycopene extracted from tomatoes; NDEA: N-Nitrosodiethylamine; RBCs: Red blood cells.