Case Control Study
Copyright ©The Author(s) 2016.
World J Hepatol. Oct 18, 2016; 8(29): 1234-1243
Published online Oct 18, 2016. doi: 10.4254/wjh.v8.i29.1234
Table 5 Interaction between MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G polymorphisms and smoking habits or alcohol drinking on the risk of liver cirrhosis
Smoking habitsAlcoholic habit

No smoker
Smoker
2Pinteraction
Non-alcoholic
Alcoholic
2Pinteraction
CaseControl1OR(95%CI)CaseControlOR+(95%CI)CaseControl1OR(95%CI)CaseControl1OR (95%CI)
MTRA2756G
A/A501421.00291211.000.39361371.00431261.000.73
A/G-G/G21571.35 (0.72-2.53)16362.07 (0.97-4.41)17531.46 (0.72-2.97)20401.74 (0.89-3.38)
MTRRA66G
A/A26551.0011501.000.05114531.0023521.000.42
A/G-G/G451440.63 (0.35-1.17)341071.71 (0.77-3.82)391371.17 (0.56-2.45)401140.78 (0.42-1.48)
MTHFRC677T
C/C31851.0017641.000.9624851.0024641.000.76
C/T-T/T401140.96 (0.54-1.71)28930.98 (0.48-2.02)291051.05 (0.54-2.02)391020.91 (0.49-1.69)
MTHFRA1298C
A/A331201.0024851.000.32231131.0034921.000.56
A/C-C/C38791.68 (0.95-3.00)21721.06 (0.53-2.13)30771.83 (0.95-3.54)29741.11 (0.61-2.03)