Polymorphisms of folate metabolism genes in patients with cirrhosis and hepatocellular carcinoma

Table 4 Interaction between MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G polymorphisms and smoking habits or alcohol drinking on the risk of hepatocellular carcinoma

	Smoking habits							Alcoholic habit
	No smoker			Smoker			2Pinteraction	Non-alcoholic			Alcoholic			2Pinteraction
	Case	Control	1OR (95%CI)	Case	Control	1OR (95%CI)		Case	Control	1OR(95%CI)	Case	Control	1OR (95%CI)
MTRA2756G
A/A	22	142	1.00	24	121	1.00	0.81	17	137	1.00	29	126	1.00	0.43
A/G-G/G	10	57	1.59 (0.65-3.87)	15	36	1.85 (0.81-4.21)		11	53	2.29 (0.91-5.72)	14	40	1.40 (0.63-3.12)
MTRRA66G
A/A	4	55	1.00	8	50	1.00	0.7	3	53	1.00	9	52	1.00	0.34
A/G-G/G	28	144	3.04 (0.95-9.71)	31	107	2.27 (0.90-5.72)		25	137	4.16 (1.11-15.55)	34	114	1.98 (0.83-4.75)
MTHFRC677T
C/C	15	85	1.00	13	64	1.00	0.55	14	85	1.00	14	64	1.00	0.75
C/T-T/T	17	114	0.80 (0.35-1.81)	26	93	1.13 (0.51-2.52)		14	105	0.86 (0.36-2.06)	29	102	1.04 (0.48-2.22)
MTHFRA1298C
A/A	13	119	1.00	19	85	1.00	0.61	11	113	1.00	21	91	1.00	0.56
A/C-C/C	19	80	2.00 (0.88-4.56)	20	72	1.49 (0.69-3.20)		17	77	2.10 (0.86-5.10)	22	75	1.49 (0.72-3.07)

¹Odds ratio (OR) adjusted for age, gender and alcohol consumption and smoking habits;

²P values significant at P ≤ 0.05.