Polymorphisms of folate metabolism genes in patients with cirrhosis and hepatocellular carcinoma

doi:10.4254/wjh.v8.i29.1234

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World Journal of Hepatology

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World J Hepatol. Oct 18, 2016; 8(29): 1234-1243
Published online Oct 18, 2016. doi: 10.4254/wjh.v8.i29.1234

Table 3 Association of MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G polymorphisms with Liver Cirrhosis, adjusted for gender, age, smoking and alcohol consumption

Model	Genotipe	Control n (%)	Case n (%)	¹OR (95%CI)	²P-value	Genotipe	Control n (%)	Case n (%)	¹OR (95%CI)	²P-value
	MTHFR C677T					MTHFR A1298C
Codominant	C/C	149 (41.9)	48 (41.4)	1		A/A	205 (57.6)	57 (49.1)	1
	C/T	174 (48.9)	55 (47.4)	0.90 (0.56-1.45)	0.56	A/C	116 (32.6)	43 (37.1)	1.27 (0.78-2.07)	0.21
	T/T	33 (9.3)	13 (11.2)	1.37 (0.64-2.95)		C/C	35 (9.8)	16 (13.8)	1.85 (0.92-3.71)
Dominant	C/C	149 (41.9)	48 (41.4)	1		A/A	205 (57.6)	57 (49.1)	1
	C/T-T/T	207 (58.1)	68 (58.6)	0.97 (0.62-1.52)	0.89	A/C-C/C	151 (42.4)	59 (50.9)	1.40 (0.90-2.18)	0.14
Recessive	C/C-C/T	323 (90.7)	103 (88.8)	1		A/A-A/C	321 (90.2)	100 (86.2)	1
	T/T	33 (9.3)	13 (11.2)	1.45 (0.71-2.99)	0.32	C/C	35 (9.8)	16 (13.8)	1.68 (0.86-3.29)	0.14
Overdominant	C/C-T/T	182 (51.1)	61 (52.6)	1		A/A-C/C	240 (67.4)	73 (62.9)	1
	C/T	174 (48.9)	55 (47.4)	0.85 (0.54-1.33)	0.47	A/C	116 (32.6)	43 (37.1)	1.14 (0.72-1.82)	0.58
Aditive	---	---	---	1.07 (0.75-1.51)	0.72	---	---	---	1.33 (0.97-1.83)	0.079
	MTR A2756G					MTRR A66G
Codominant	A/A	263 (73.9)	79 (68.1)	1		A/A	105 (29.5)	37 (31.9)	1
	A/G	83 (23.3)	32 (27.6)	1.52 (0.91-2.53)	0.13	A/G	179 (50.3)	55 (47.4)	0.94 (0.56-1.56)	0.95
	G/G	10 (2.8)	05 (4.3)	2.47 (0.75-8.12)		G/G	72 (20.2)	24 (20.7)	0.91 (0.49-1.71)
Dominant	A/A	263 (73.9)	79 (68.1)	1		A/A	105 (29.5)	37 (31.9)	1
	A/G-G/G	93 (26.1)	37 (31.9)	1.60 (0.98-2.61)	0.06	A/G-G/G	251 (70.5)	79 (68.1)	0.93 (0.58-1.50)	0.77
Recessive	A/A-A/G	346 (97.2)	111 (95.7)	1		A/A-A/G	284 (79.8)	92 (79.3)	1
	G/G	10 (2.8)	5 (4.3)	2.19 (0.68-7.09)	0.21	G/G	72 (20.2)	24 (20.7)	0.95 (0.55-1.64)	0.86
Overdominant	A/A-G/G	273 (76.7)	84 (72.4)	1		A/A-G/G	177 (49.7)	61 (52.6)	1
	A/G	83 (23.3)	32 (27.6)	1.46 (0.88-2.41)	0.15	A/G	179 (50.3)	55 (47.4)	0.97 (0.62-1.52)	0.9
Aditive	---	---	---	1.54 (1.02-2.33)	0.042	---	---	---	0.95 (0.70-1.30)	0.77

¹Odds ratio (OR) adjusted for age, gender and alcohol consumption and smoking habits;

²P values significant at P ≤ 0.05.

Citation: Peres NP, Galbiatti-Dias ALS, Castanhole-Nunes MMU, da Silva RF, Pavarino ÉC, Goloni-Bertollo EM, Ruiz-Cintra MT. Polymorphisms of folate metabolism genes in patients with cirrhosis and hepatocellular carcinoma. World J Hepatol 2016; 8(29): 1234-1243
URL: https://www.wjgnet.com/1948-5182/full/v8/i29/1234.htm
DOI: https://dx.doi.org/10.4254/wjh.v8.i29.1234