Polymorphisms of folate metabolism genes in patients with cirrhosis and hepatocellular carcinoma

Table 2 Association of MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G polymorphisms with hepatocellular carcinoma, adjusted for gender, age, smoking and alcohol consumption

Model	Genotipe	Controln (%)	Case n (%)	1OR (95%CI)	2P-value	Genotipe	Controln (%)	Case n (%)	1OR (95%CI)	2P-value
	MTHFR C677T					MTHFR A1298C
Codominant	C/C	149 (41.9)	28 (39.4)	1		A/A	205 (57.6)	32 (45.1)	1
	C/T	174 (48.9)	36 (50.7)	0.93 (0.51-1.68)	0.91	A/C	116 (32.6)	24 (33.8)	1.29 (0.69-2.42)	0.014
	T/T	33 (9.3)	7 (9.9)	1.13 (0.41-3.09)		C/C	35 (9.8)	15 (21.1)	3.37 (1.52-7.50)
Dominant	C/C	149 (41.9)	28 (39.4)	1		A/A	205 (57.6)	32 (45.1)	1
	C/T-T/T	207 (58.1)	43 (60.6)	0.96 (0.54-1.70)	0.88	A/C-C/C	151 (42.4)	39 (54.9)	1.71 (0.98-2.99)	0.06
Recessive	C/C-C/T	323 (90.7)	64 (90.1)	1		A/A-A/C	321 (90.2)	56 (78.9)	1
	T/T	33 (9.3)	7 (9.9)	1.18 (0.46-3.05)	0.73	C/C	35 (9.8)	15 (21.1)	3.04 (1.43-6.47)	0.0051
Overdominant	C/C-T/T	182 (51.1)	35 (49.3)	1		A/A-C/C	240 (67.4)	47 (66.2)	1
	C/T	174 (48.9)	36 (50.7)	0.91 (0.52-1.59)	0.73	A/C	116 (32.6)	24 (33.8)	0.99 (0.55-1.78)	0.98
Aditive	---	---	---	1.01 (0.64-1.58)	0.97	---	---	---	1.71 (1.16-2.52)	0.007
	MTR A2756G					MTRR A66G
Codominant	A/A	263 (73.9)	46 (64.8)	1		A/A	105 (29.5)	12 (16.9)	1
	A/G	83 (23.3)	21 (29.6)	1.58 (0.84-2.98)	0.13	A/G	179 (50.3)	50 (70.4)	3.26 (1.54-6.87)	< 0.001
	G/G	10 (2.8)	4 (5.6)	3.29 (0.81-13.30)		G/G	72 (20.2)	9 (12.7)	1.16 (0.44-3.11)
Dominant	A/A	263 (73.9)	46 (64.8)	1		A/A	105 (29.5)	12 (16.9)	1
	A/G-G/G	93 (26.1)	25 (35.2)	1.73 (0.95-3.15)	0.078	A/G-G/G	251 (70.5)	59 (83.1)	2.55 (1.24-5.25)	0.0072
Recessive	A/A-A/G	346 (97.2)	67 (94.4)	1		A/A-A/G	284 (79.8)	62 (87.3)	1
	G/G	10 (2.8)	4 (5.6)	2.91 (0.73-11.59)	0.15	G/G	72 (20.2)	9 (12.7)	0.51 (0.23-1.12)	0.077
Overdominant	A/A-G/G	273 (76.7)	50 (70.4)	1		A/A-G/G	177 (49.7)	21 (29.6)	1
	A/G	83 (23.3)	21 (29.6)	1.49 (0.80-2.79)	0.22	A/G	179 (50.3)	50 (70.4)	3.05 (1.66-5.62)	< 0.001
Aditive	---	---	---	1.68 (1.01-2.77)	0.047	---	---	---	1.16 (0.77-1.73)	0.48

¹Odds ratio (OR) adjusted for age, gender and alcohol consumption and smoking habits;

²P values significant at P ≤ 0.05.