Polymorphisms of folate metabolism genes in patients with cirrhosis and hepatocellular carcinoma

Table 1 Relationship between risk factors and hepatocellular carcinoma and liver cirrhosis development

Variables	Controls n (%)	Cirrhosis n (%)	1OR (95%CI)	P-value	HCC n (%)	OR (95%CI)	2P
Age
< 46 anos	238 (67)	22 (19)	10.31 (5.66-18.76)	P < 0.001	8 (11)	16.36 (6.68-40.05)	P < 0.001
≥ 46 anos	118 (33)	94 (81)			63 (89)
Genre
Female	95 (26.7)	30 (25.9)	0.96 (0.54-1.72)	P = 0.893	19 (26.8)	0.59 (0.29-1.22)	P = 0.154
Male	261 (73.3)	86 (74.1)			52 (73.2)
Alcoholic habit
Not	191 (54)	54 (46.6))	1.55 (0.91-2.63)	P = 0.106	27 (38)	2.01 (1.03-3.89)	P = 0.039
Yes	165 (46)	62 (53.4)			44 (62)
Smoking habit
Nonsmokers	199 (56)	72 (62)	0.47 (0.28-0.78)	P = 0.003	31 (43.7)	0.9 (0.48-1.67)	P = 0.734
Smokers	157 (44)	44 (38)			40 (56.3)

¹Odds ratio (OR) adjusted for age, genre, alcohol consumption, smoking habits and polymorphisms;

²P values significant at P ≤ 0.05. HCC: Hepatocellular carcinoma.