Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma

Table 2 Comparative analysis of the N-Nitrosodiethylamine and lycopene extracted from tomatoes + N-Nitrosodiethylamine group by scanning electron microscopy

Groups/parameters	NDEA	LycT + NDEA
Cell density	+++	+
Rounding of hepatocytes	+++	+
Trabecular structures	-	+++
Necrotic tumor nodules	+++	+
Apoptotic bodies	-	+++
Type of HCC	Undifferentiated	Well-differentiated

Where “+++” indicates that more than 70%-90% of mice in a group showed this feature; “+” indicates that < 70% of mice showed this feature; “-” indicates that the < 20% of mice showed this feature. LycT: Lycopene extracted from tomatoes; NDEA: N-Nitrosodiethylamine; HCC: Hepatocellular carcinoma.