Review
Copyright ©The Author(s) 2016.
World J Hepatol. Oct 8, 2016; 8(28): 1157-1168
Published online Oct 8, 2016. doi: 10.4254/wjh.v8.i28.1157
Table 1 Epidemiological characteristics associated with the three autoimmune liver diseases
PBCPSCAIH
Female/male ratio10/11/24/1
Average age at presentation5041Childhood/adolescence and approximately 40
Incidence0.33-5.8/1000000-1.3/1000000.08-3/100000
Prevalence1.91-40.2/1000000-16.2/10000011.6-35.9/100000
Risk within family1st degree relative incidence 4%-6%UnknownUnknown
Concordance in monozygotic twins60%Only case reportsOnly case reports
NoteAMA positivityFrequent association with IBD Increased risk of hepatobiliary/colorectal malignanciesPositivity for ANA and or SMA (AIH type-1) or anti-LKM-1 (AIH type-2)