Immune response to hepatitis B virus vaccine in celiac subjects at diagnosis

Table 2 Patient characteristics and distribution of human leukocyte antigens and clinical features

	Responders	Non-responders	P value
HBV vaccination	34 (69.4%)	15 (30.6%)
Female sex	22 (66.7%)	11 (33.3%)
Male sex	12 (75%)	4 (25%)
Median age	5.55 (± 3.25 SDS)	8.04 (± 4.3 SDS)	> 0.05
HLA
DQ2/DQ2	8	4
DQ2/DQ8	6	1
Other HLA1	19	10
Distribution according HLA			> 0.05
Clinical form of CD
Typical form	20	6
Atypical form	11	6
Silent form	3	3
Distribution according clinical form			> 0.05

¹Includes heterozygosis for HLA DQ2, heterozygosis for HLA DQ8 and homozygosis for HLA DQ8 patients. HBV: Hepatitis B virus; CD: Celiac disease; SDS: Standard deviation score; HLA: Human leukocyte antigens.