Reversal of multidrug resistance of hepatocellular carcinoma cells by metformin through inhibiting NF-κB gene transcription

Figure 2 Metformin enhances adriamycin-induced apoptosis of HepG2/adriamycin cells. Cell early apoptosis was measured by Annexin-V-PE/7-AAD double staining assay in triplicate. A: The blank group (untreated); B: The control group (only treated with adriamycin); C: The experiment group (treated with metformin plus adriamycin). AAD: AnnexinV apoptosis detection.