Cholesterol metabolism in cholestatic liver disease and liver transplantation: From molecular mechanisms to clinical implications

Figure 3 Cholesterol elimination- mechanisms and key transporters. Expansion of the cholesterol pool activates liver X receptor, thereby generating transcriptional responses resulting in cholesterol excretion and catabolism. NPC1L1: Niemann-Pick C1 like 1; ABCA1: ATP-binding cassette transporter sub-family member A 1, also known as the cholesterol efflux regulatory protein; ACAT2: Acetyl-CoA acyltransferase 2; ABCG5: Adenosine triphosphate-binding cassette transporter G5 heterodimer; HDL: High density lipoprotein.