Cholesterol metabolism in cholestatic liver disease and liver transplantation: From molecular mechanisms to clinical implications

Figure 2 One key event in cholesterol homeostasis is the gated movement of sterol regulatory element-binding protein isoform 2 from the endoplasmic reticulum to the Golgi complex, involving the cleavage-activating protein, and INSIG-2. SREBP-2: Sterol regulatory element-binding protein isoform 2; ER: Endoplasmic reticulum; SCAP: Cleavage-activating protein.