Redefining Budd-Chiari syndrome: A systematic review

Table 2 Signs and symptoms in classical Budd-Chiari syndrome and hepatic vena cava-Budd Chiari syndrome

	Classical BCS									HVC-BCS
	Perellóet al[40]	Darwish Murad et al[24]	Sakr et al [22]	Rautou et al[46]	Raszeja-Wyszomirska et al[45]	Westbrook et al[32]	D'Amico et al[34]	Harmanci et al[42]	Nozari et al[47]	De et al[23]	Xu et al[41]	Ebrahimi et al[46]	Qi et al[35]	Cheng et al[13]	Gao et al[49]
															R vs NR
Country	Spain	Europe	Egypt	France	Poland	United Kingdom	Italy	Sweden	Iran	India	China	Iran	China	China	China
n (%)	21	163	94	94	20	66	31	62	55	40	1360	21	169	145	98	373
Abdominal pain	18 (86)	99 (61)	78 (83)			36 (55)		28 (45)	33 (60)	28 (70)	122 (9)	5 (29)		30 (21)
Ascites	18 (86)	135 (83)	80 (85)	73 (78)	20 (100)	57 (87)			42 (76)	30 (75)	914 (67)	19 (90)	95 (56)	77 (53)	76 (78)	224 (60)
Hepatomegaly	9 (43)	109 (67)	78 (83)						33 (60)	38 (95)	1124 (83)	8 (38)		40 (28)	61 (62)	165 (44)
Splenomegaly		85 (52)	48 (51)						19 (34)	26 (65)	683 (50)			113 (78)
Abdominal wall varices			39 (41)							38 (95)	821 (60)		50 (30)	73 (50)
Esophageal varices		45 (58)1		53 (56)			18 (58)
Lower extremity edema			46 (49)					28 (45)		28 (70)		14 (67)	86 (51)	76 (52)
Jaundice	10 (48)		36 (38)						10 (18)	15 (38)	116 (9)
Encephalopathy	1 (5)	15 (9)	29 (31)	7 (7)		32 (48)						12 (57)	1 (1)
Bleeding episodes	1 (5)	8 (5)	15 (16)		5 (25)		7 (23)			6 (15)	162 (12)		25 (15)	31 (21)
Duration of symptoms	1.42	< 1						1-6	6				44	96
Chronic, > 6 mo		23 (14)	75 (80)3					25 (40)	21 (38)	30 (75)				125 (86)
Acute, < 6 mo		138 (85)	18 (19)					37 (60)	34 (62)					20 (14)

¹77 patients underwent EGD;

²Mean, not median. Most studies reported median duration of symptoms in months; when the median was not available, the mean is reported;

³No definition of “chronic” was provided. BCS: Budd-Chiari syndrome; HVC: Hepatic vena cava; R: Recurrence of BCS; NR: Non-recurrence of BCS.