Combined acoustic radiation force impulse, aminotransferase to platelet ratio index and Forns index assessment for hepatic fibrosis grading in hepatitis B

Table 3 Cut-off values of acoustic radiation force impulse and aspartate aminotransferase to platelet ratio index for the diagnosis of liver fibrosis (95%CI)

	≥ F1	≥ F2	≥ F3	F4
ARFI
Cut-off (m/s)	1.26	1.29	1.43	1.62
Sensitivity	76.2% (69.80-81.90)	83.6% (77.10-88.90)	82.3% (74.00-88.80)	90.7% (79.70-96.90)
Specificity	95.0% (83.10-99.40)	90.1% (89.50-97.60)	89.5% (83.00-94.10)	92.2% (87.40-95.60)
PPV	99.1% (96.20-99.90)	94.5% (91.90-99.10)	86.9% (79.10-92.70)	76.0% (64.40-86.30)
NPV	35.9% (22.50-47.40)	73.0% (63.10-81.40)	85.6% (78.60-91.00)	97.2% (93.70-99.10)
AUROC	0.90 (0.86-0.94)a	0.91 (0.87-0.95)a	0.94 (0.90-0.96)a	0.96 (0.93-0.98)a
APRI
Cut-off (m/s)	0.30	0.41	0.49	0.44
Sensitivity	84.0% (78.20-88.70)	68.5% (60.80-75.50)	63.7% (54.10-72.60)	83.3% (70.70-92.10)
Specificity	85.0% (70.20-94.30)	82.7% (72.70-90.20)	79.7% (71.90-86.20)	67.2% (70.10-73.80)
PPV	97.6% (94.20-99.30)	89.0% (82.20-93.80)	72.8% (62.90-81.20)	41.7% (32.30-51.60)
NPV	42.7% (30.00-56.10)	56.3% (46.80-65.40)	72.1% (64.00-79.20)	93.5% (87.90-97.00)
AUROC	0.92 (0.88-0.95)a	0.84 (0.79-0.89)a	0.79 (0.73-0.84)a	0.82 (0.76-0.86)a

^aP < 0.05 for all values. ARFI: Acoustic radiation force impulse; APRI: Aspartate aminotransferase to platelet ratio index; AUCROC: Area under the receiver operating characteristic curve; NPV: Negative predictive value; PPV: Positive predictive value.