Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy

Table 2 Clinical features of primary biliary cirrhosis

Clinical features	Prevalence	Mechanism
Fatigue	20%-85%[55,56,58]	Excessive manganese deposits in globus pallidum, elevated inflammatory cytokines
Pruritus	20%-75%[35,58]	Cholestasis, increased opiodergic tone
Jaundice	10%-60%[58]	Cholestasis
Xanthomas	15%-50%[58]	Hypercholesterolemia and hyperlipidemia[56]
Osteoporosis	35%[59]	Disturbances in bone remodeling due to metabolic changes in PBC
Dyslipidemia	> 75%[60]	Reduction in biliary secretion of cholesterol. Toxic effects of unconjugated bilirubin

PBC: Primary biliary cirrhosis.