Impact of all oral anti-hepatitis C virus therapy: A meta-analysis

Table 2 Pooled outcome data

Regimen	Type	n	SVR (%)	SAE (%)	DDR (%)	Cost/wk ($)	Cost/SVR ($)
P + R	Naïve	14	49.4 (42.7-56.2)	10.1 (7.2-14.0)	9 (5.3-14.9)	900	87449
P + R	NR	5	18.5 (15.2-22.4)	7.9 (5.5-11.3)	3.5 (2.1-5.7)	900	233514
TEL or BOC based with P/R	Naïve	8	74.5 (67.8-80.2)	9.4 (6.7-13.0)	11.9 (6.5-20.7)	2300	148188
TEL or BOC based with P/R	NR	4	62.6 (55.9-68.7)	13.7 (11.3-16.5)	12.5 (9.8-15.8)	2300	176358
SOF or SIM based with P/R	Naïve	9	90.3 (83.6-94.4)	5.4 (1.9-12.5)	2.5 (1.1-5.4)	6900	91694
SOF or SIM based with P/R	NR	4	95.9 (91.5-98.1)	6.8 (1.1-12.8)	1.9 (0.5-7.1)	6900	86340
DAA + R	Naïve	5	92.3 (82.9-96.7)	3.1 (1.3-6.8)	0.9 (0.3-2.6)	12200	158613
DAA +R	NR	4	95.9 (91.5-98.1)	3.3 (1.1-9.9)	1.9 (0.5-7.1)	12200	152659
2 DAA, No P/R	Naïve	4	96.4 (93.6-98.0)	1.9 (0.6-5.7)	0.9 (0.3-2.7)	12000	149378
2 DAA, No P/R	NR	3	94.1 (88.9-97.0)	2.3 (0.6-8.8)	1.4 (0.3-6.5)	12000	153029

DAA: Direct acting antivirals; P: Peg interferon; R: Ribavirin; TEL: Telaprevir; BOC: Boceprevir; SOF: Sofosbuvir; SIM: Simeprevir; NR: Non-responders; SVR: Sustained viral response; SAE: Serious adverse events; DDR: Drug discontinuation rate.