Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics

doi:10.4254/wjh.v7.i3.583

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Mar 27, 2015 (publication date) through Jan 8, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Mar 27, 2015; 7(3): 583-592
Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.583

Table 4 Representative mutations and clinical characteristics

Region	Mutation	Clinical characteristics
Pre-S/S	P120S/E, K122R, T126A, P127T, Q129H/R, L134S, K141E, P142S, D144A/E/V, G145R/A	OBI/HBsAg decrease
Pre-S/S	Pre-S deletion	HCC
Pre-C/C	A1896T, G1899A	HBe seroconversion HCC
X	C1653T, T1753C, A1762T, G1764A	HCC
P	L180M, A181V, T184G, S202I, M204V/I N236T, M250V	NA resistance

S: Surface; OBI: Occult hepatitis B virus infection; HCC: Hepatocellular carcinoma; HBe: Hepatitis B e; HBsAg: Hepatitis B s antigen.

Citation: Yano Y, Azuma T, Hayashi Y. Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics. World J Hepatol 2015; 7(3): 583-592
URL: https://www.wjgnet.com/1948-5182/full/v7/i3/583.htm
DOI: https://dx.doi.org/10.4254/wjh.v7.i3.583