Recurrence of autoimmune liver diseases after liver transplantation

Table 2 Diagnostic criteria for recurrent primary biliary cirrhosis after liver transplantation[49]

Confirmed diagnosis of PBC in the explant histology

Characteristic histologic features1

Lymphoplasmacytic portal infiltrate

Lymphoid aggregates

Epithelioid granulomas

Evidence of bile duct injury

Persistence of AMA or AMA-M2

Exclusion of other causes of graft dysfunction

Acute and chronic rejection

Graft vs host disease

Bile flow impairment or cholangitis

Vascular complications

Viral hepatitis

Drug induced hepatitis

¹Definite recurrent PBC: 3 of 4 portal tract lesions are observed; Probable recurrent PBC: 2 of 4 portal tract lesions are observed. PBC: Primary biliary cirrhosis; AMA: Anti-mitochondrial antibodies.