Comparison of peg-interferon, ribavirin plus telaprevir vs simeprevir by propensity score matching

Table 2 Univariate and multivariate analysis of factors associated with sustained virological response following pegylated interferon, ribavirin, and telaprevir or simeprevir triple therapy

Parameters	Telaprevir			Simeprevir
	SVR	Non-SVR	P value	SVR	Non-SVR	P value
Unmatched patients
Univariate analysis	n = 126	n = 33		n = 102	n = 45
Age (yr)	58.0 (51.0-65.0)	62.0 (59.6-65.5)	NS	61.0 (52.8-67.3)	66.0 (56.5-71.0)	0.016
Gender (male/female)	62/64	15/18	NS	48/54	19/26	NS
Body mass index (kg/m2)	23.8 (21.7-25.7)	24.6 (21.7-26.0)	NS	23.2 (21.0-25.1)	23.5 (21.3-26.0)	NS
Level of viremia (log IU/mL)	6.7 (6.3-7.0)	6.6 (6.3-7.0)	NS	6.8 (6.2-7.1)	6.9 (6.4-7.3)	NS
Leukocyte count (/mm3)	5100 (4200-5700)	5100 (4400-6600)	NS	5000 (4300-5800)	4800 (3800-5800)	NS
Hemoglobin (g/dL)	14.1 (13.2-15.1)	14.1 (12.8-14.8)	NS	13.9 (13.1-14.7)	13.7 (12.7-14.8)	NS
Platelet count (× 104/mm3)	15.0 (12.8-19.8)	15.0 (12.5-20.1)	NS	15.3 (11.9-20.5)	15.0 (11.1-18.3)	NS
SNP of IL28B (TT/non-TT)	84/19	15/15	< 0.001	72/19	17/24	< 0.001
Multivariate analysis	Odds ratio (95%CI)			Odds ratio (95%CI)
SNP of IL28B (TT/non-TT)	4.316 (1.804-10.327)		0.001	8.598 (3.388-21.817)		< 0.001
Age (yr)				0.933 (0.889-0.980)		0.006
Level of viremia (log IU/mL)				0.335 (0.157-0.715)		0.005
Propensity score matched patients
Univariate analysis	n = 77	n = 27		n = 76	n = 28
Age (yr)	60.0 (52.5-66.5)	64.0 (60.0-65.0)	NS	59.0 (51.0-66.0)	65.0 (56.0-71.0)	0.021
Gender (male/female)	33/44	12/15	NS	37/39	12/16	NS
Body mass index (kg/m2)	23.1 (20.6-25.0)	24.0 (21.4-26.6)	NS	23.2 (21.3-25.1)	23.6 (21.1-26.1)	NS
Level of viremia (log IU/mL)	6.7 (6.3-7.0)	6.7 (6.4-6.9)	NS	6.7 (6.1-7.0)	6.6 (6.3-7.2)	NS
Leukocyte count (/mm3)	5000 (4100-5700)	5100 (4400-6700)	NS	5100 (4400-5900)	4600 (3500-5700)	NS
Hemoglobin (g/dL)	14.0 (13.1-14.8)	13.9 (13.0-14.9)	NS	14.0 (12.9-15.0)	13.8 (12.9-14.7)	NS
Platelet count (× 104/mm3)	15.0 (12.3-19.7)	15.4 (12.9-20.3)	NS	15.1 (11.9-20.4)	15.0 (11.0-17.2)	NS
SNP of IL28B (TT/non-TT)	61/16	13/14	0.002	61/15	12/16	< 0.001
Multivariate analysis	Odds ratio (95%CI)			Odds ratio (95%CI)
SNP of IL28B (TT/non-TT)	7.739 (2.111-28.375)		0.002	8.594 (2.777-26.598)		< 0.001

Values are presented as numbers or medians with interquartile ranges in parentheses. P-values were calculated using the χ² test or Mann-Whitney U-test for continuous variables. SNP: Single-nucleotide polymorphism; IL28: Interleukin 28B; SVR: Sustained virological response; NS: Not significant.