Long noncoding RNAs in hepatocellular carcinoma: Novel insights into their mechanism

Table 2 Downregulated long noncoding RNAs in hepatocellular carcinoma

Name	Gene locus	Size (bp)	Dysregulation	Potential role in HCC	Ref.
MEG3 (GTL2)	14q32.3	34919	Downregulated	Associate with methylation. Predictive biomarker for monitoring epigenetic therapy	[21,83-87]
LncRNA-LET	15q24.1	2606	Downregulated	Reduces hepatic invasion and abdominal metastases	[88]
PTENP1	9p13.3	3917	Downregulated	Repress the tumorigenic properties of HCC cells	[22,89]
SRHC	5p15.31	6365	Downregulated	Inhibit cancer proliferation	[90]
MT1DP	16q13	1255	Downregulated	Act as a tumor suppressor. Overexpression of MT1DP decreases cell proliferation but increases apoptosis	[91]

HCC: Hepatocellular carcinoma; MT1DP: Metallothionein 1D, pseudogene; MEG3: Maternally expressed gene 3; LncRNA: Long noncoding RNA.