Importance of virological response in the early stage of telaprevir-based triple therapy for hepatitis C

doi:10.4254/wjh.v7.i26.2688

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Nov 18, 2015; 7(26): 2688-2695
Published online Nov 18, 2015. doi: 10.4254/wjh.v7.i26.2688

Table 1 Patient characteristics

	All (n = 253)	SVR (n = 207)	Non-SVR (n = 46)	P value
Sex, male (%)	123 (48.6)	108 (52.2)	15 (32.6)	0.0153
Age (yr)	61 (12.5)	60 (12)	63.5 (11.25)	0.0340
Body mass index (kg/m²)	23.4 (3.9)	23.4 (3.9)	23.9 (3.8)	0.2198
Baseline HCV RNA (log10 IU/mL)	6.5 (0.9)	6.5 (0.9)	6.4 (0.7)	0.4468
IL28B SNP (rs8099917), TT/TG or GG (%)¹	186/65 (74.1/25.9)	166/40 (80.6/19.4)	20/25 (44.4/55.6)	< 0.0001
ITPA SNP (rs1127354), CC/CA or AA (%)¹	193/58 (76.9/23.1)	157/49 (76.2/23.8)	36/9 (80.0/20.0)	0.5802
Hemoglobin level (g/L)	138 (22)	140 (21)	134 (20)	0.0031
Platelet count (× 10⁹/L)	157 (69)	159 (65)	129 (69)	0.0006
Serum albumin (g/L)	40 (6.0)	40 (6.0)	39 (5.0)	0.0143
Aspartate aminotransferase (U/L)	48 (42)	46 (43)	59 (34.5)	0.0350
Alanine aminotransferase (U/L)	54 (58)	53 (64)	58 (44)	0.4955
γ-glutamyl-transpeptidase (U/L)	40 (51)	39 (47)	46 (59)	0.1270
LDL-cholesterol (mg/dL)	95 (38)	98 (36)	75 (35)	< 0.0001
Ferritin (μg/L)	164.6 (232.3)	160.5 (223.2)	181.7 (253.9)	0.3583
Estimated glomerular filtration rate (mL/min per 1.73 m²)	79.4 (19.1)	79.7 (18.9)	77.7 (19.4)	0.6210
Response to previous PegIFN-α/RBV therapy				< 0.0001
Treatment naïve, n (%)	92 (36.4)	81 (39.4)	11 (23.9)
Prior relapse, n (%)	113 (44.7)	100 (48.1)	13 (28.3)
Prior non-response, n (%)	48 (19.0)	26 (12.5)	22 (44.8)
Liver histology
Stage, F0-2/F3-4 (%)	96/58 (62.3/37.7)	87/38 (69.6/30.4)	9/20 (31.0/69.0)	< 0.0001
Grade, A0-1/A2-3 (%)	54/100 (35.1/64.9)	45/80 (36.0/64.0)	9/20 (31.0/69.0)	0.614
Not determined, n	99	82	17

¹IL28B and ITPA SNPs were not available for only two patients (1.2%). Continuous variables are expressed as median (interquartile range). P value draws a comparison between SVR and non-SVR patients. SVR: Sustained virological response; HCV: Hepatitis C virus; IL28B: Interleukin 28B; SNP: Single-nucleotide polymorphism; ITPA: Inosine triphosphate pyrophosphatase; LDL: Low-density lipoprotein; PegIFN: Pegylated interferon; RBV: Ribavirin.

Citation: Hiramine S, Furusyo N, Ogawa E, Nakamuta M, Kajiwara E, Nomura H, Dohmen K, Takahashi K, Satoh T, Azuma K, Kawano A, Koyanagi T, Kotoh K, Shimoda S, Hayashi J. Importance of virological response in the early stage of telaprevir-based triple therapy for hepatitis C. World J Hepatol 2015; 7(26): 2688-2695
URL: https://www.wjgnet.com/1948-5182/full/v7/i26/2688.htm
DOI: https://dx.doi.org/10.4254/wjh.v7.i26.2688