Histopathological differences utilizing the nonalcoholic fatty liver disease activity score criteria in diabetic (type 2 diabetes mellitus) and non-diabetic patients with nonalcoholic fatty liver disease

Table 3 Histological findings of patients with nonalcoholic fatty liver disease, divided according to nonalcoholic fatty liver disease without type 2 diabetes mellitus and nonalcoholic fatty liver disease with type 2 diabetes mellitus n (%)

Parameter	All patients (n = 235)	NAFLD (without T2DM) (n = 158)	NAFLD (with T2DM) (n = 77)	P value
NAS score (mean ± SD)	3.2 ± 1.7	3.0 ± 1.6	3.5 ± 1.7	0.03
Fibrosis score (mean ± SD)	0.75 ± 1.1	0.52 ± 0.9	1.2 ± 1.3	< 0.01
Fibrosis score				< 0.01
< 2	191 (81.3)	139 (88.0)	52 (67.5)
≥ 2	44 (18.7)	19 (12.0)	25 (32.5)
NAS score				0.12
< 5	179 (76.2)	125 (79.1)	54 (70.1)
≥ 5	56 (23.8)	33 (20.9)	23 (29.9)
NAS score				0.11
< 3	90 (38.3)	66 (41.7)	24 (31.2)
≥ 3	145 (61.7)	92 (58.3)	53 (68.8)
Steatosis				0.1
< 2	97 (41.3)	71 (44.9)	26 (33.8)
≥ 2	138 (58.7)	87 (55.1)	51 (66.2)
Ballooning				< 0.01
< 2	193 (82.1)	137 (86.7)	56 (72.7)
2	42 (17.9)	21 (13.3)	21 (27.3)
Inflammation				0.4
< 2	218 (92.7)	148 (93.7)	70 (90.9)
≥ 2	17 (7.3)	10 (6.3)	7 (9.1)
Mallory bodies	50 (21.3)	28 (17.7)	22 (28.6)	0.06

NAFLD: Nonalcoholic fatty liver disease; NAS: NAFLD activity score; T2DM: Type 2 diabetes mellitus.