Histopathological differences utilizing the nonalcoholic fatty liver disease activity score criteria in diabetic (type 2 diabetes mellitus) and non-diabetic patients with nonalcoholic fatty liver disease

Table 2 Characteristics of patients with nonalcoholic fatty liver disease, divided according to nonalcoholic steatohepatitis and steatosis (mean + SD)

Parameter	All patients (n = 235)	NASH	Steatosis	P value
Age (yr)	45.3 + 11.9	45.9 + 12.4	43.8 + 10.4	0.2
Gender (male/female)	91/144	67/101	24/43	0.6
Race (% caucasian)	65.1	64.9	65.7	0.1
BMI (kg/m2)	37.7 + 11.5	37 + 10.6	39.4 + 13.7	0.17
Hypertension, n (%)	114 (48.5)	82 + 48.8	32 + 63.9	1
Dyslipidemia, n (%)	139 (68.8)	100 (70.9)	39 (63.9)	0.3
Metabolic syndrome, n (%)	115 + 53.7	67 (42.7)	32 (56.1)	0.08
Platelets	258 + 73.5	247 + 72.1	283 + 71.1	< 0.01
INR	0.996 + 0.162	1 + 0.178	0.98 + 0.112	0.3
Protein (g/dL)	7.39 + 0.762	7.39 + 0.733	7.37 + 0.714	0.8
Albumin (g/dL)	4.27 + 0.536	4.27 + 0.555	4.26 + 0.487	0.8
AST (U/L)	49.8 + 34.5	54.2 + 36.3	38.3 + 26.1	< 0.01
ALT (U/L)	72.6 + 58.5	78.7 + 63.1	57 + 40.7	0.01
Bilirubin (mg/dL)	0.668 + 0.416	0.71 + 0.456	0.567 + 0.275	0.01
Alkaline Phosphate	96.7 + 61.8	100 + 70.9	88.3 + 28.3	0.1
Total cholesterol (mg/dL)	200 + 47.3	202 + 48.6	197 + 44.5	0.5
HDL cholesterol (mg/dL)	44.4 + 11.9	42.7 + 10.7	48.1 + 13.6	0.01
Triglycerides (mg/dL)	211 + 120	220 + 125	191 + 105	0.18
LDL cholesterol (mg/dL)	1119 + 41	121 + 41.6	114 + 39.8	0.33
Fasting glucose (mg/dL)	126 + 55.5	129 + 55.9	117 + 53.8	0.14
HbA1c	6.93 + 2.09	7.12 + 2.19	6.37 + 1.69	0.11
Iron (μg/dL)	82.6 + 38.7	83.8 + 40.5	78.6 + 31.9	0.52
Total iron binding capacity (μg/dL)	322 + 72.3	319 + 74.6	335 + 63.4	0.31
Ferritin (ng/mL)	258 + 306	276 + 324	201 + 232	0.21
Mallory bodies	50 + 21.3	50 + 29.8	0	< 0.01
CAD	67 + 28.9	50 + 29.9	17 + 26.2	0.63
Gastric bypass	21 + 8.94	14 + 8.33	7 + 10.4	0.61
Cirrhosis	14 + 5.96	14 + 8.33	0	0.01
Steatosis	1.92 + 0.861	2.1 + 0.83	1.46 + 0.765	< 0.01
Inflammation	0.44 + 0.62	0.625 + 0.663	0	< 0.01
Fibrosis	0.753 + 1.11	1.05 + 1.21	0	< 0.01
Ballooning	0.821 + 0.712	1.15 + 0.575	0	< 0.01
NAS score	3.18 + 1.69	3.86 + 1.45	1.46 + 0.765	< 0.01

AST: Aspartate transaminase; ALT: Alanine transaminase; HDL: High-density lipoprotein cholesterol; NAS: Nonalcoholic fatty liver disease activity score; NASH: Nonalcoholic steatohepatitis; LDL: Low-density lipoprotein cholesterol; BMI: Body mass index; INR: International normalized ratio; CAD: Coronary artery disease.