Roles of lipoprotein receptors in the entry of hepatitis C virus

Figure 3 Structure of low-density lipoprotein receptor and its relevance for hepatitis C virus entry. LDLR is structurally composed by four motifs: LDLR type A repeats, which is the main binding site for ligand; an epidermal growth factor-like domain, which is response to the change of pH to release ligand; a transmembrane anchor and a cytoplasmic domain, which mediates clustering of the receptors into the clathrin-coated pit. LDLR: Low-density lipoprotein receptor.