Roles of lipoprotein receptors in the entry of hepatitis C virus

Figure 2 Model of scavenger receptor class B type I topology and its relevance for hepatitis C virus entry. The SR-BI regions comprise cytoplasmic C-terminal and N-terminal domains separated by a large extracellular domain. Cholesterol uptake and HCV entry is mainly mediated by extracellular domain. Particularly, C323 is critical for SR-BI-mediated cholesterol ester uptake. Amino acids 70-87 and the single residue E210 of SR-BI are required for E2 recognition in HCV entry. SR-BI: Scavenger receptor class B type I; HCV: Hepatitis C virus; HDL: High-density lipoprotein; JAK/STAT: Janus kinase/signal transducer and activator of transcription.