Roles of lipoprotein receptors in the entry of hepatitis C virus

Figure 1 Process of hepatitis C virus cell entry. After being captured by DC-SIGN and L-SIGN, virions with apolipoprotein may first attach a host cell by interacting with LDLR on the cell surface (1), following by binding to CD81 and SR-BI (2), and finally by a later utilization of the tight junction protein CLDN1 and OCLN (3). HCV: Hepatitis C virus; SR-BI: Scavenger receptor class B type I; LDLR: Low-density lipoprotein receptor; CLDN-1: Claudin-1; OCLN: Occluding.