Benefits of nucleos(t)ide analog treatments for hepatitis B virus-related cirrhosis

Table 1 Studies characterizing the natural history of hepatitis B-related cirrhosis

Ref.	Publication year	Country	Number of patients with cirrhosis	5-yr survival for patients with compensated cirrhosis (%)	Cause of death
Weissberg et al[4]	1984	United States	130	55	Liver failure (70.3%)
					Unrelated disease (18.9%)
					Unknown causes (10.8%)
Liaw et al[5]	1989	Taiwan	76	80	Hepatic failure or variceal bleeding (100%)
de Jongh et al[6]	1992	The Netherlands	98	71	Hepatocellular carcinoma (38.5%)
					Liver failure or fatal upper gastrointestinal bleeding (38.5%)
					Unrelated disease (23.1%)
Realdi et al[7]	1994	Italy	366	84	Liver failure (53.6%)
					Hepatocellular carcinoma (27.4%)
					Unrelated disease (19.0%)